Yea theres a few issues with ACF:
1. It seems to be explicitly breaking when memcached is enabled.
2. There seems to be no good or official way to serialize a posts variety of fields. Each field is an individual piece of post_meta. It would be really great if ACF just serialized all an objects fields or if it gave us the option when building out fields to say fields a b and c while visually different fields should be stored on one post_meta entry.