Well, if you use the standard admin theme (not any custom in admin area) it shouldnt matter there since it’s based on wordpress own classes..
As far as front end editing goes you’re not restricted to only using ACFs own front end form.. You could create your own form or possibly use for example Gravityform for it and use filters (for gravity forms) or a custom submit page to save the values to the users profile. You could even create your very own form with completely custom markup and styling and write some AJAX to save it to user profile without reload or requirement of a submitpage
