Hi @peder77
Yes. This is what I would do:
1. Create a backup of your current DB
2. Update in increments of each version
To update in increments, use this url (http://wordpress.org/plugins/advanced-custom-fields/developers/) to download the latest version 2.
Replace the files within ‘advanced-custom-fields’ folder (in wp-plugins) with the contents of the .zip
Then, do again for v3.0.0, then again for the latest v3, then v4.0.0, then the latest v4
That should work a treat!