Removing the tinyMCE validation throws this error:
Uncaught ReferenceError: tinyMCE is not defined
Naturally I included wp-includes/js/tinymce/tiny_mce.js
and got this error:
Uncaught TypeError: Cannot set property 'theme_advanced_buttons1' of undefined
Diving deeper…
As a first attempt, since the errors produced are due to ACF attempting to reset tinyMCE settings, I tried simply commenting out the lines that reset the settings, thus throwing this error.