Hi Elliot,
I think the conflict is in your script, perhaps they changed something with Iris in the last WordPress update. If you remove line 1203 from input.js $input.trigger('change');
then the color picker works as expected: I don’t know if this has any impact on anything else, but it may help you look further.
event.returnValue is only used in wp-auth-check.js and jQuery itself so I don’t think this is a related issue.
Daniel