Hi @willthemoor
The flexible content field will be your best bet for creating the editing interface for this level of customized content.
I agree that you should use a select field in each layout to allow for layout specific alteration such as column width and alignment.
You can also use some conditional logic to hide sub fields within the layout if you fear that there may be too many fields at once.
As for the pull quote issue, perhaps think about using shortcodes in your WYSIWYG field to allow for the alignment instead of classes.
Good luck
Thanks
E
