Yes, but you need to create an acf/save_post filter https://www.advancedcustomfields.com/resources/acf-save_post/ that gets the values from the custom fields and populates the post title and content with wp_update_post() https://codex.wordpress.org/Function_Reference/wp_update_post. There is a good example of generating a title from acf fields here https://stackoverflow.com/questions/54245106/auto-fill-a-custom-post-type-title-from-acf-field
