Hi @sbmdesigns
Sure, you can include all custom post fields (generated by ACF) in permalink URL plugin thanks to the plugin:
https://github.com/athlan/wordpress-custom-fields-permalink-plugin
You can also define custom fields on-the-fly like get the post permalink from specific field using hooks:
https://github.com/athlan/wordpress-custom-fields-permalink-plugin/wiki/ACF-plugin-support
Cheers,
Athlan