As far as I know, only if you’re using something like switch_to_blog and the blog you’re switching somehow has a different return format set for the field. Even here, I’m not sure. If for example the first time ACF loads the field with that field name/key. Whatever return value is loaded then is what will be used since it will be cached so that ACF does not query the DB again. Outside of this there would need to be some filter that’s altering the return value setting for the field.
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