Hi @yosef
You can use update_field() in the acf/save_post to update the fields in CPT B based on the CPT A.
You can also query CPT A first on search, get the returned IDs, then query the CPT B based on the returned IDs. This page should give you more idea about it: http://www.advancedcustomfields.com/resources/query-posts-custom-fields/.
I hope this makes sense. Thanks!