Actually I think most layouts can be achieved but instead of shortcodes you can work more with page templates and/or flexible field from ACF.
I’ve created a completely modular page layout for a client with up to eight columns of content just by using the flexible field and they love it!
Big + that they don’t need to worry about shortcodes in their content either.
Welcome to the Advanced Custom Fields community forum.
Browse through ideas, snippets of code, questions and answers between fellow ACF users