Yes it works – it works with a little bit knowledge using the perfect example from Hube – but it works also with standard ACF functions. You should use a standard select field with UI and AJAX activated. Your PHP action load_field should be set for this field and load the correct data. This is for both fields. Your second field should “hear” on $_POST[‘your_var_brand’] and then you should do a little bit work on your JS file…..
acf.addFilter('select2_ajax_data', function( data, args, $input, field, instance )
I have used this in my actual plugin project in 15 fields and it works great.
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