Solved it. For reference, build the query as if your were querying multiple custom fields. This frees up the ‘meta_key’ option for use in ordering.
Example:
'post_type' => 'post',
'showposts' => -1,
'meta_query' => array(
'relation' => 'AND',
array(
'key' => 'acf_field',
'value' => 'acf_field_value',
'compare' => '='
)
),
'meta_key' => 'acf_number_field',
'orderby' => 'meta_value_num',
'order' => 'ASC'